ORIGINAL ARTICLE: Activation of TLR3 in the Trophoblast is Associated with Preterm Delivery

2009176 citationsJournal Articlegreen Open Access

Authors

Kaori Koga · Yale University

Ingrid Cardenas · Yale University

Paulomi Aldo · Yale University

Vikki M. Abrahams · Yale University

Bing Peng · Yale University

Sara Fill Malfertheiner · Yale University

Roberto Romero · Eunice Kennedy Shriver National Institute of Child Health and Human Development

Abstract

We report that Poly[I:C] induces preterm delivery via TLR3-dependent manner. Furthermore, we demonstrate that the trophoblast is able to recognize Poly[I:C] through TLR3 and respond to viral infection, modulating the immune system at the feto-maternal interface.

Topics & Keywords

Preterm Birth and Chorioamnionitis Immune Response and Inflammation Reproductive System and Pregnancy

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Reproductive Immunology

Volume 61, Issue 3, pp. 196-212

DOI: 10.1111/j.1600-0897.2008.00682.x

Field-Weighted Citation Impact: 7.60