Brief Communication : Adriamycin-Induced Cardiac Damage in the Mouse: A Small-Animal Model of Cardiotoxicity

1975119 citationsJournal Article

Authors

Abstract

After one dose of adriamycin, a subacute cardiomyopathy was observed in the mouse by both light and electron microscopy. The microscopic alterations were characterized by single-cell necrosis and mitochondrial degeneration. These lesions were similar to those seen in man and shortly preceded fatal toxicity.

Topics & Keywords

Chemotherapy-induced cardiotoxicity and mitigation Cardiac electrophysiology and arrhythmias Cardiovascular Function and Risk Factors

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 55, Issue 1, pp. 191-194

DOI: 10.1093/jnci/55.1.191

Field-Weighted Citation Impact: 3.67