A YAC contig map of the human genome.

1995326 citationsJournal Article

Authors

I M Chumakov · Fondation Jean Dausset-CEPH

Philippe Rigault

I Le Gall

Christine Bellanné‐Chantelot

Abstract

A yeast artificial chromosome library containing 33,000 clones with an average insert size of one megabase of human genomic DNA was extensively analysed by several different procedures for detecting overlaps and positional information. We developed an analysis strategy that resulted, after confirmatory tests, in a YAC contig map reliably covering about 75% of the human genome in 225 contigs having an average size of about ten megabases.

Topics & Keywords

Machine Learning in Bioinformatics Genetics, Bioinformatics, and Biomedical Research RNA and protein synthesis mechanisms

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: PubMed

Volume 377, Issue 6547 Suppl, pp. 175-297

DOI: 10.1038/377175a0

Field-Weighted Citation Impact: 24.90