Fast and sensitive multiple alignment of large genomic sequences

2003199 citationsJournal Articlegold Open Access

Authors

Michael A. Chapman · University of Cambridge

Berthold Göttgens · University of Cambridge

Burkhard Morgenstern · University of Göttingen

Abstract

We conclude that the novel CHAOS local alignment tool is an effective way to significantly speed up global alignment tools such as DIALIGN without reducing the alignment quality. We likewise demonstrate that the DIALIGN/CHAOS combination is able to accurately align short regulatory sequences in distant orthologues.

Topics & Keywords

Genomics and Phylogenetic Studies Algorithms and Data Compression RNA and protein synthesis mechanisms

Publication Details

Published in: BMC Bioinformatics

Volume 4, Issue 1, pp. 66-66

DOI: 10.1186/1471-2105-4-66

Field-Weighted Citation Impact: 6.83

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Fast and sensitive multiple alignment of large genomic sequences

Authors

Abstract

Topics & Keywords

Publication Details