Enzyme Inhibition: Mechanisms and Scope

Enzyme is a protein molecule acting as catalyst in enzyme reaction. Enzyme inhibition is a science of enzyme-substrate reaction influenced by the presence of any organic chemical or inorganic metal or biosynthetic compound due to their covalent or non-covalent interactions with enzyme active site. It is well known that all these inhibitors follow same rule to interplay in enzyme reaction. Present chapter introduces beginners with basic tenets of classic presumptions of enzyme inhibition, types of enzyme inhibitors, different models of enzyme inhibition with established examples cited in literature, and scientific basis of emerging immobilized enzyme technology in different applications. In the end, limitations of using classic presumptions and variants of enzyme inhibition are highlighted with new challenges to achieve best results. Present time, best approach is 'customize new technology with detailed analysis to make it highly efficient' in both drug discovery and enzyme biosensor industry. However, other applications are described in following chapters on pesticides, herbicides.