m-Calpain is required for preimplantation embryonic development in mice

2006150 citationsJournal Articlehybrid Open Access

Authors

Previn Dutt · Queen's University

Dorothy E. Croall · University of Maine

J. Simon C. Arthur · MRC Protein Phosphorylation and Ubiquitylation Unit

Teresa De Veyra · Queen's University

Karen Williams · Queen's University

John S. Elce · Queen's University

Peter A. Greer ·

Abstract

We conclude that homozygous disruption of the Capn2 gene results in pre-implantation embryonic lethality between the morula and blastocyst stage. This establishes that mu-calpain and m-calpain have distinct functions, and that m-calpain is vital for development of the preimplantation murine embryo.

Topics & Keywords

Calpain Protease Function and Regulation Cell death mechanisms and regulation Protein Kinase Regulation and GTPase Signaling

Publication Details

Published in: BMC Developmental Biology

Volume 6, Issue 1, pp. 3-3

DOI: 10.1186/1471-213x-6-3

Field-Weighted Citation Impact: 3.17

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m-Calpain is required for preimplantation embryonic development in mice

Authors

Abstract

Topics & Keywords

Publication Details