Identification of novel insulin mimetic drugs by quantitative total internal reflection fluorescence (<scp>TIRF</scp>) microscopy

201434 citationsJournal Articlehybrid Open Access

Authors

Peter Lanzerstorfer · University of Applied Sciences Upper Austria

Verena Stadlbauer · University of Applied Sciences Upper Austria

Lilia A. Chtcheglova · Aerospace & Advanced Composites (Austria)

Renate Haselgrübler · University of Applied Sciences Upper Austria

Daniela Borgmann · University of Applied Sciences Upper Austria

Jürgen Wruss · University of Applied Sciences Upper Austria

Abstract

Taken together, the results indicate that TIRF microscopy is an excellent tool for the quantification of GLUT4 translocation and for identifying insulin mimetic drugs.

Topics & Keywords

Metabolism, Diabetes, and Cancer Protein Kinase Regulation and GTPase Signaling Glycosylation and Glycoproteins Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Pharmacology

Volume 171, Issue 23, pp. 5237-5251

DOI: 10.1111/bph.12845

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