Dysregulation of Histone Acetylation in the APP/PS1 Mouse Model of Alzheimer's Disease

2009302 citationsJournal Articlegreen Open Access

Authors

Yitshak I. Francis · University College London

Mauro Fà · Columbia University

Haider Ashraf · Columbia University

Hong Zhang · Columbia University

Agnieszka Staniszewski · Columbia University

David S. Latchman · University College London

Ottavio Arancio ·

Abstract

Epigenetic mechanisms such as post-translational histone modifications are increasingly recognized for their contribution to gene activation and silencing in the brain. Histone acetylation in particular has been shown to be important both in hippocam

Topics & Keywords

Alzheimer's disease research and treatments Nuclear Receptors and Signaling Genetics and Neurodevelopmental Disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Alzheimer s Disease

Volume 18, Issue 1, pp. 131-139

DOI: 10.3233/jad-2009-1134

Field-Weighted Citation Impact: 8.40