Disruption of nNOS‐PSD95 protein–protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents

2009105 citationsJournal Articlebronze Open Access

Authors

SK Florio · Amgen (United States)

Christine Loh · EKOS Corporation

S-M Huang · Johns Hopkins University

AE Iwamaye · Brown University

KF Kitto · University of Minnesota

K.F. Fowler · EKOS Corporation

JA Treiberg · Gilead Sciences (Canada)

Abstract

nNOS-PSD95 interaction is important in maintaining hypersensitivity in acute and chronic pain. Disruption of the nNOS-PSD95 interaction provides a novel approach to obtain selective anti-hyperalgesic compounds.

Topics & Keywords

Pain Mechanisms and Treatments Ion channel regulation and function Pharmacological Receptor Mechanisms and Effects

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Pharmacology

Volume 158, Issue 2, pp. 494-506

DOI: 10.1111/j.1476-5381.2009.00300.x

Field-Weighted Citation Impact: 2.70