Single agent versus combination chemotherapy for metastatic breast cancer

2009305 citationsReviewbronze Open Access

Authors

Sue Carrick · University of Melbourne

Sharon K. Parker

Charlene Thornton · Western Sydney University

Davina Ghersi · National Health and Medical Research Council

John Simes · National Health and Medical Research Council

Nicholas Wilcken

Abstract

Combination chemotherapy regimens show a statistically significant advantage for survival, tumor response and time to progression in women with metastatic breast cancer but they also produce more toxicity. An unresolved question is whether combination regimens are more effective than single agents given sequentially.

Topics & Keywords

Cancer Treatment and Pharmacology Breast Cancer Treatment Studies HER2/EGFR in Cancer Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cochrane Database of Systematic Reviews

Volume 2021, Issue 5, pp. CD003372-CD003372

DOI: 10.1002/14651858.cd003372.pub3

Field-Weighted Citation Impact: 12.31