Thiopurine methyl-transferase activity and azathioprine metabolite concentrations do not predict clinical outcome in thiopurine-treated inflammatory bowel disease patients

201186 citationsJournal Articlebronze Open Access

Authors

Yago González‐Lama · Hospital Universitario Puerta de Hierro Majadahonda

Fernando Bermejo

Antonio López–Sanromán · Hospital Universitario Ramón y Cajal

Valle García–Sánchez · Hospital Universitario Reina Sofía

María Esteve · University Hospital Mútua de Terrassa

José Luis Cabriada · Hospital de Galdakao

Adrián G. McNicholl · Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

Abstract

Our results do not support determination of TPMT activity or 6TGN concentrations to predict treatment outcome, and no useful serum metabolites threshold value to adjust the drug's dose was identified.

Topics & Keywords

Acute Lymphoblastic Leukemia research Inflammatory Bowel Disease Microscopic Colitis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Alimentary Pharmacology & Therapeutics

Volume 34, Issue 5, pp. 544-554

DOI: 10.1111/j.1365-2036.2011.04756.x

Field-Weighted Citation Impact: 12.92