Iron-Chelating Therapy and the Treatment of Thalassemia

19971,104 citationsJournal Articlebronze Open Access

Authors

Nancy F. Olivieri · Hospital for Sick Children

Gary M. Brittenham · Hospital for Sick Children

Abstract

THE LAST 3 decades have witnessed profound changes in the management of patients with thalassemia major. Regular red blood cell (RBC) transfusions eliminate the complications of anemia and compensatory bone marrow (BM) expansion, permit normal development throughout childhood, and extend survival.[1

Topics & Keywords

Hemoglobinopathies and Related Disorders Iron Metabolism and Disorders Neonatal Health and Biochemistry

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Blood

Volume 89, Issue 3, pp. 739-761

DOI: 10.1182/blood.v89.3.739

Field-Weighted Citation Impact: 27.77