Inhibition of Glutathione S-Transferase by Ethacrynic Acid Augments Ischemia-Reperfusion Damage and Apoptosis and Attenuates the Positive Effect of Ischemic Postconditioning in a Bilateral Acute Hindlimb Ischemia Rat Model

20157 citationsJournal Article

Authors

Tibor Nagy

Viktória Kovács

Péter Hardi

Tünde Gyöngyvér Veres

Örs Pintér · University of Pecs

Endre Arató

Abstract

Inhibition of GST by EA augmented the IR damage. GST inhibition was associated with a different activation of the mitogen-activated protein kinases and the PSP, regulating these pathways in the process of apoptosis and PC.

Topics & Keywords

Glutathione Transferases and Polymorphisms Eicosanoids and Hypertension Pharmacology Genomics, phytochemicals, and oxidative stress

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Vascular Research

Volume 52, Issue 1, pp. 53-61

DOI: 10.1159/000381984

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