Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes

20154,311 citationsJournal Articlebronze Open Access

Authors

Christopher P. Cannon · Brigham and Women's Hospital

Michael A. Blazing

Robert P. Giugliano · Brigham and Women's Hospital

Amy McCagg · Brigham and Women's Hospital

Jennifer A. White

Pierre Théroux · Montreal Heart Institute

Harald Darius · Vivantes Klinikum

Basil S. Lewis

Abstract

When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit. (Funded by Merck; IMPROVE-IT ClinicalTrials.gov number, NCT00202878.).

Topics & Keywords

Lipoproteins and Cardiovascular Health Cancer, Lipids, and Metabolism Antiplatelet Therapy and Cardiovascular Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 372, Issue 25, pp. 2387-2397

DOI: 10.1056/nejmoa1410489

Field-Weighted Citation Impact: 452.29