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Abstract There are now more than three hundred city-regions around the world with populations greater than one million. These city-regions are expanding vigorously, and they present many new and deep challenges to researchers and policy-makers in both the more developed and less developed parts of the world. The processes of global economic integration and accelerated urban growth make traditional planning and policy strategies in these regions increasingly inadequate, while more effective approaches remain largely in various stages of hypothesis and experimentation. 'Global City-Regions' represents a multifaceted effort to deal with the many different issues raised by these developments. It seeks at once to define the question of global city-regions and to describe the internal and external dynamics that shape them; it proposes a theorization of global city-regions based on their economic and political responses to intensifying levels of globalization; and it offers a number of policy insights into the severe social problems that confront global city-regions as they come face to face with an economically and politically neoliberal world. At a moment when globalization is increasingly subject to critical scrutiny in many different quarters, this book provides a timely overview of its effects on urban and regional development, one of its most important (but perhaps least understood) corollaries. The book also offers a series of nuanced visions of alternative possible futures.