Angiotensin II Receptor Antagonism Reduces Transforming Growth Factor Beta and Smad Signaling in Thoracic Aortic Aneurysm.

201347 citationsJournal Articlegreen Open Access

Authors

Maria Nataatmadja · University of Queensland

Sulistiana Prabowo · Universitas Hang Tuah

Abstract

Increased TGF-β and Smad3 expression in aneurysm tissue and cultured VSMCs is consistent with aberrant TGF-β expression and the activation of Smad3 signaling. Losartan-mediated reduction in TGF-β expression and the cytoplasmic localization of Smad3 support a role for AT1R antagonism in the inhibition of aneurysm progression.

Topics & Keywords

Connective tissue disorders research Aortic aneurysm repair treatments Aortic Disease and Treatment Approaches

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PubMed

Volume 13, Issue 1, pp. 42-8

Field-Weighted Citation Impact: 2.05