Regulation of MMP-9 activity in human tear fluid and corneal epithelial culture supernatant.

2000206 citationsJournal Article

Authors

Lucia Sobrin

Zuguo Liu · Ocular Surface Center

Dagoberto Monroy · Ocular Surface Center

Abraham Solomon · Ocular Surface Center

Marie G. Selzer · University of Miami

Balakrishna L. Lokeshwar · University of Miami

Stephen C. Pflugfelder · Ocular Surface Center

Abstract

MMP-9 and TIMP-1 are produced by the human corneal epithelium and are present in tear fluid. MMP-3 alone is sufficient to activate MMP-9 on the ocular surface. Doxycycline does not directly inhibit this activation by MMP-3, but it decreases MMP-9 activity when added to corneal epithelial cultures.

Topics & Keywords

Protease and Inhibitor Mechanisms Ocular Surface and Contact Lens Blood Coagulation and Thrombosis Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PubMed

Volume 41, Issue 7, pp. 1703-9

Field-Weighted Citation Impact: 3.52