Pronecrotic mixed lineage kinase domain‐like protein expression is a prognostic biomarker in patients with early‐stage resected pancreatic adenocarcinoma

2013125 citationsJournal Articlebronze Open Access

Authors

Lauren E. Colbert · Emory University

Sarah B. Fisher · Emory University

Claire Hardy · Emory University

William A. Hall · Emory University

Burcu Saka · Emory University

Joseph W. Shelton · Emory University

Aleksandra V. Petrova ·

Abstract

Low expression of MLKL is associated with decreased OS in patients with resected PAC and decreased RFS and OS in the subset of patients with resected PAC who receive adjuvant chemotherapy. The use of this biomarker in patients with PAC may provide important prognostic information.

Topics & Keywords

Pancreatic and Hepatic Oncology Research Pancreatitis Pathology and Treatment Phagocytosis and Immune Regulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancer

Volume 119, Issue 17, pp. 3148-3155

DOI: 10.1002/cncr.28144

Field-Weighted Citation Impact: 4.55