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The sections in this article are: 1 Carbon Dioxide Content of Blood 1.1 Dissolved CO2 1.2 Bicarbonate Ion 1.2.1 Hydration-Dehydration Kinetics 1.2.2 Carbonic Anhydrase 1.3 Carbamate Compounds 1.3.1 Carbamate Formation in Plasma 1.3.2 Hemoglobin Carbamates 2 Carbon Dioxide Dissociation Curve 2.1 Buffering of CO2 2.2 Distribution of CO2 Content Between Cells and Plasma 2.2.1 Erythrocytes 2.2.2 Plasma 2.3 Haldane Effect 2.4 Relative Contributions to CO2 Exchange 3 Time-Dependent Factors in CO2 Exchange 3.1 Diffusion of CO2 3.2 Dehydration of Carbonic Acid 3.2.1 Intracellular Dehydration 3.2.2 Plasma Dehydration 3.3 Bicarbonate-Chloride Exchange 3.3.1 Speed of Bicarbonate-Chloride Shift 3.3.2 Mechanism of Anionic Exchange 3.4 Interaction of CO2 and O2 Exchange 3.4.1 Oxylabile Carbamate Kinetics 3.4.2 Oxylabile Bicarbonate Kinetics 3.5 Models of Gas Exchange