Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth.

2002303 citationsJournal Article

Authors

Elia J. Duh · Johns Hopkins University

Hoseong S. Yang

Abstract

These data indicate that elevated concentrations of PEDF inhibit VEGF-induced retinal endothelial cell growth and migration and retinal neovascularization. These findings suggest that localized administration of PEDF may be an effective approach for the treatment of ischemia-induced retinal neovascular disorders.

Topics & Keywords

Retinal Diseases and Treatments Retinal Development and Disorders Advanced Glycation End Products research

UN Sustainable Development Goals

Life below water

Publication Details

Published in: PubMed

Volume 43, Issue 3, pp. 821-9

Field-Weighted Citation Impact: 18.64