Different gDNA content in the subpopulations of prostate cancer extracellular vesicles: Apoptotic bodies, microvesicles, and exosomes

2014276 citationsJournal Articlehybrid Open Access

Authors

Elisa Lázaro‐Ibáñez · University of Helsinki

Andrés Sanz-García · University of Helsinki

Tapio Visakorpi · Tampere University Hospital

Carmen Escobedo‐Lucea · University of Helsinki

Pia Siljander · University of Helsinki

Ángel Ayuso‐Sacido · University of Helsinki

Marjo Yliperttula

Abstract

EVs derived from PCa cell lines and human plasma samples contain double-stranded gDNA fragments which could be used to detect specific mutations, making EVs potential biomarkers for cancer diagnostics and prognostics.

Topics & Keywords

Extracellular vesicles in disease MicroRNA in disease regulation RNA Interference and Gene Delivery

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Prostate

Volume 74, Issue 14, pp. 1379-1390

DOI: 10.1002/pros.22853

Field-Weighted Citation Impact: 10.53