Genome Analysis of Latin American Cervical Cancer: Frequent Activation of the PIK3CA Pathway

201592 citationsJournal Articlegreen Open Access

Authors

Hong Lou · Leidos (United States)

Guillermo Villagran · Liga Nacional Contra el Cáncer

Joseph F. Boland · Leidos (United States)

Kate M. Im · Frederick National Laboratory for Cancer Research

Sarita Polo · Liga Nacional Contra el Cáncer

Weiyin Zhou · Leidos (United States)

Ushie Odey

Abstract

PI3K pathway mutation is important to cervical carcinogenesis in Latin America. Therapeutic agents that directly target PI3K could play a role in the therapy of this common malignancy.

Topics & Keywords

BRCA gene mutations in cancer Cancer Genomics and Diagnostics Viral-associated cancers and disorders

UN Sustainable Development Goals

No poverty

Publication Details

Published in: Clinical Cancer Research

Volume 21, Issue 23, pp. 5360-5370

DOI: 10.1158/1078-0432.ccr-14-1837

Field-Weighted Citation Impact: 6.92