Extracellular Hsp90 mediates an NF‐κB dependent inflammatory stromal program: Implications for the prostate tumor microenvironment

201382 citationsJournal Articlegreen Open Access

Authors

JE Bohonowych · Medical University of South Carolina

MW Hance · Medical University of South Carolina

KD Nolan · Medical University of South Carolina

Michael DeFee · Medical University of South Carolina

CH Parsons · Medical University of South Carolina

JS Isaacs · Medical University of South Carolina

Abstract

Our results provide compelling support for eHsp90α as a transducer of signaling events culminating in an inflammatory and reactive stroma, thereby conferring properties associated with prostate cancer progression.

Topics & Keywords

Heat shock proteins research Healthcare and Venom Research NF-κB Signaling Pathways

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Prostate

Volume 74, Issue 4, pp. 395-407

DOI: 10.1002/pros.22761

Field-Weighted Citation Impact: 3.14