Blood pressure lowering effect of diuretics as second line therapy for primary hypertension in crossover trials

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: Primary objective To quantify the additional reduction in systolic blood pressure (SBP) and diastolic blood pressure (DBP) of diuretics as second‐line therapy in patients with primary hypertension based on cross‐over trials. Secondary objectives To quantify the effects of a second‐line diuretic on heart rate (HR). To quantify the effects of a second‐line diuretic on withdrawals due to adverse effects (WDAE).