Control of <scp>TMEM16A</scp> by <scp>INO</scp>‐4995 and other inositolphosphates

201241 citationsJournal Article

Authors

Yuemin Tian · University of Regensburg

Rainer Schreiber · University of Regensburg

Podchanart Wanitchakool · University of Regensburg

Patthara Kongsuphol · University of Regensburg

Marisa Sousa · University of Lisbon

Inna Uliyakina · University of Lisbon

Marta Palma ·

Abstract

These data indicate that TMEM16A is the target for INO-4995, although the mode of action appears different for overexpressed and endogenous channels. INO-4995 may be useful for the treatment of CF lung disease.

Topics & Keywords

Ion channel regulation and function Ion Transport and Channel Regulation Neuroscience of respiration and sleep

Publication Details

Published in: British Journal of Pharmacology

Volume 168, Issue 1, pp. 253-265

DOI: 10.1111/j.1476-5381.2012.02193.x

Field-Weighted Citation Impact: 1.44

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Control of <scp>TMEM16A</scp> by <scp>INO</scp>‐4995 and other inositolphosphates

Authors

Abstract

Topics & Keywords

Publication Details