Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells

2011135 citationsJournal Articlebronze Open Access

Authors

Radhamani Kannaiyan · National University of Singapore

Hui Sin Hay · National University of Singapore

Peramaiyan Rajendran · National University of Singapore

Feng Li · National University of Singapore

Muthu K. Shanmugam · National University of Singapore

Shireen Vali · Cellworks Research (India)

Taher Abbasi

Abstract

Thus, based on our experimental findings, we conclude that celastrol may have great potential as a treatment for MM and other haematological malignancies.

Topics & Keywords

Natural Compounds in Disease Treatment Multiple Myeloma Research and Treatments Cell death mechanisms and regulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Pharmacology

Volume 164, Issue 5, pp. 1506-1521

DOI: 10.1111/j.1476-5381.2011.01449.x

Field-Weighted Citation Impact: 34.62