The programmed death 1/programmed death ligand 1 inhibitory pathway is up‐regulated in rheumatoid synovium and regulates peripheral T cell responses in human and murine arthritis

2010197 citationsJournal Article

Authors

Amalia Raptopoulou · University of Crete

George Βertsias · University of Crete

Dimitrios Makrygiannakis · Karolinska Institutet

Panagiotis Verginis · University of Crete

Iraklis Kritikos · University of Crete

Maria Tzardi · University of Crete

Lars Klareskog ·

Abstract

The negative costimulatory PD-1/PDL-1 pathway regulates peripheral T cell responses in both human and murine RA. PD-1/PDL-1 in rheumatoid synovium may represent an additional target for immunomodulatory therapy in RA.

Topics & Keywords

T-cell and B-cell Immunology Rheumatoid Arthritis Research and Therapies Monoclonal and Polyclonal Antibodies Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Arthritis & Rheumatism

Volume 62, Issue 7, pp. 1870-1880

DOI: 10.1002/art.27500

Field-Weighted Citation Impact: 1.24