Involvement of CYP1A2 in mexiletine metabolism

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Authors

Masatoshi Nakajima · Showa Pharmaceutical University

Kaoru Kobayashi · Showa University

Noriaki Shimada

Shinkan Tokudome · Tokyo Medical Examiner's Office

Toshinori Yamamoto · Showa University

Yukio Kuroiwa · Showa University

Abstract

Mexiletine is a substrate of CYP1A2. The data obtained in this study suggest that the interaction of mexiletine with theophylline might be due to competitive inhibition of CYP1A2.

Topics & Keywords

Pharmacogenetics and Drug Metabolism Drug Transport and Resistance Mechanisms Analytical Chemistry and Chromatography

Publication Details

Published in: British Journal of Clinical Pharmacology

Volume 46, Issue 1, pp. 55-62

DOI: 10.1046/j.1365-2125.1998.00048.x

Field-Weighted Citation Impact: 4.52

Command Palette

Involvement of CYP1A2 in mexiletine metabolism

Authors

Abstract

Topics & Keywords

Publication Details