Mediation of calcium-independent contraction in trabecular meshwork through protein kinase C and rho-A.

200080 citationsJournal Article

Authors

Hagen Thieme · Humboldt-Universität zu Berlin

Michael Nuskovski

Abstract

The data indicate that contrary to CM, the TM features calcium-independent contractile mechanisms linked to rho-A and PKC isoforms that do not require calcium for activation. ROCK inhibitors may allow specific modulation of the TM to enhance outflow facility, thus lowering intraocular pressure.

Topics & Keywords

Protein Kinase Regulation and GTPase Signaling Glycogen Storage Diseases and Myoclonus Cellular transport and secretion

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: PubMed

Volume 41, Issue 13, pp. 4240-6

Field-Weighted Citation Impact: 1.43