<i>FTO</i> Obesity Variant Circuitry and Adipocyte Browning in Humans

20151,373 citationsJournal Articlebronze Open Access

Authors

Melina Claussnitzer · Helmholtz Zentrum München

Simon N. Dankel · Haukeland University Hospital

Kyoung-Han Kim · SickKids Foundation

Gerald Quon · German Research Centre for Artificial Intelligence

Wouter Meuleman · German Research Centre for Artificial Intelligence

Christine E. Haugen · Haukeland University Hospital

Viktoria Glunk

Abstract

Our results point to a pathway for adipocyte thermogenesis regulation involving ARID5B, rs1421085, IRX3, and IRX5, which, when manipulated, had pronounced pro-obesity and anti-obesity effects. (Funded by the German Research Center for Environmental Health and others.).

Topics & Keywords

RNA Research and Splicing RNA modifications and cancer Cancer-related molecular mechanisms research

Publication Details

Published in: New England Journal of Medicine

Volume 373, Issue 10, pp. 895-907

DOI: 10.1056/nejmoa1502214

Field-Weighted Citation Impact: 72.76

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<i>FTO</i> Obesity Variant Circuitry and Adipocyte Browning in Humans

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Abstract

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Publication Details