Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells

2011145 citationsJournal Articlebronze Open Access

Authors

Ning Wang · University of Hong Kong

Weidong Pan · Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences

Meifen Zhu · University of Hong Kong

Maosheng Zhang · Zunyi Medical University

Xiao-Jian Hao · Kunming Institute of Botany

Liang Guang-yi · Guiyang College of Traditional Chinese Medicine

Yibin Feng

Abstract

Fangchinoline is a highly specific agent inducing autophagic cell death in hepatocellular carcinoma cells with a novel mechanism, which elucidates the potential of fangchinoline to potentiate programmed cell death in cancer cells.

Topics & Keywords

Autophagy in Disease and Therapy Polyamine Metabolism and Applications Ubiquitin and proteasome pathways

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Pharmacology

Volume 164, Issue 2b, pp. 731-742

DOI: 10.1111/j.1476-5381.2011.01349.x

Field-Weighted Citation Impact: 5.09