Decreased BDNF, trkB-TK+ and GAD<sub>67</sub> mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders

2011349 citationsJournal Articlebronze Open Access

Authors

Cynthia Shannon Weickert · Schizophrenia Research Institute

Eugene Wyatt · Neuroscience Research Australia

Maree J. Webster · Stanley Medical Research Institute

Abstract

Our findings show abnormal BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders, indicating that fundamental properties of hippocampal signalling transmission, plasticity and circuitry may be affected in individuals with these major mental illnesses.

Topics & Keywords

Nerve injury and regeneration Neurogenesis and neuroplasticity mechanisms Neuroscience and Neuropharmacology Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Psychiatry and Neuroscience

Volume 36, Issue 3, pp. 195-203

DOI: 10.1503/jpn.100048

Field-Weighted Citation Impact: 12.73