Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E<sub>2</sub> synthase‐1

200982 citationsJournal Articlebronze Open Access

Authors

Federica Pollastro · Probiotical (Italy)

Hinnak Northoff · University of Tübingen

Abstract

MC is the first natural product to inhibit mPGES-1 that efficiently suppresses PGE(2) formation without significant inhibition of the COX enzymes. This provides an interesting pharmacological profile suitable for interventions in inflammatory disorders, without the typical side effects of coxibs and non-steroidal anti-inflammatory drugs.

Topics & Keywords

Inflammatory mediators and NSAID effects Bioactive Compounds and Antitumor Agents Genomics, phytochemicals, and oxidative stress

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Pharmacology

Volume 156, Issue 6, pp. 952-961

DOI: 10.1111/j.1476-5381.2009.00070.x

Field-Weighted Citation Impact: 6.44