Embryonic Stem Cell Immunogenicity Increases Upon Differentiation After Transplantation Into Ischemic Myocardium

2005332 citationsJournal Article

Authors

Rutger‐Jan Swijnenburg · Leiden University

Masashi Tanaka · Leiden University

Hannes Vogel · Leiden University

Jeanette Baker · Leiden University

Theo Kofidis · Leiden University

Feny Gunawan · Leiden University

Darren R. Lebl · Leiden University

Abstract

In vivo differentiated ESCs elicit an accelerated immune response as compared with undifferentiated ESCs. These data imply that clinical transplantation of allogeneic ESCs or ESC derivatives for treatment of cardiac failure might require immunosuppressive therapy.

Topics & Keywords

Pluripotent Stem Cells Research Mesenchymal stem cell research Tissue Engineering and Regenerative Medicine

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 112, Issue 9_supplement, pp. I166-72

DOI: 10.1161/circulationaha.104.525824

Field-Weighted Citation Impact: 10.60