Defective hypothalamic response to immune and inflammatory stimuli in patients with rheumatoid arthritis

1992341 citationsJournal Article

Authors

Gabrielle Kingsley · St Thomas' Hospital

George P. Chrousos · National Institutes of Health

G S Panayi · National Institute of Oncology

Abstract

These findings suggest that RA patients have an abnormality of the HPA axis response to immune/inflammatory stimuli which may reside in the hypothalamus. This hypothalamic abnormality may be an additional, and hitherto unrecognized, factor in the pathogenesis of RA.

Topics & Keywords

Stress Responses and Cortisol Adrenal Hormones and Disorders Dermatology and Skin Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Arthritis & Rheumatism

Volume 35, Issue 11, pp. 1281-1288

DOI: 10.1002/art.1780351107

Field-Weighted Citation Impact: 7.33