Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil

1999178 citationsJournal Articlebronze Open Access

Authors

Timothy S. Tracy · West Virginia University

Kenneth R. Korzekwa · University of Pittsburgh

Frank J. Gonzalez · National Cancer Institute

Abstract

These results confirm that P450s 3A4, 3A5 and 2C8 play a major role in verapamil metabolism and demonstrate that norverapamil can also be further metabolized by the P450s.

Topics & Keywords

Pharmacogenetics and Drug Metabolism Drug Transport and Resistance Mechanisms Pharmacological Effects and Toxicity Studies

Publication Details

Published in: British Journal of Clinical Pharmacology

Volume 47, Issue 5, pp. 545-552

DOI: 10.1046/j.1365-2125.1999.00923.x

Field-Weighted Citation Impact: 6.47

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Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil

Authors

Abstract

Topics & Keywords

Publication Details