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the place of informed leadership coupled with general fiscal difficulties are hindering realization of knowledge and benefit to society.The solution requires more than the corporate mold of The increasing politicization of the support of science has awakened many a scientist to the risks and realities of survival as an investigator and to the threats to the future of science.Effective management and wise leadership of the scientific enterprise are necessary solutions to the dilemma.Sir Walter Bodmer shares his perspective regarding the principles of successful scientific management from his experience in leading the Imperial Cancer Research Fund (ICRF) as well as his being in the forefront of science.Yes! Management is necessary.But to be effective it must not displace leadership or the recognition and pursuit of excellence.It must be nonintrusive.Naive management imperatives in management.It must encompass a variety of actions based in the fundamental principle that management supports the optimal conduct of science.Dr. Bodmer guides us through these principles with clarity, experience, and vision.The principles of excellence, balance, and strategic insight have each been key ingredients in the success of the ICRF and are applicable at large.