Pyridoxine inhibits endothelial NOS uncoupling induced by oxidized low‐density lipoprotein via the PKCα signalling pathway in human umbilical vein endothelial cells

Pyridoxine mitigated eNOS uncoupling induced by ox-LDL. This protectant effect was related to phosphorylation of eNOS Thr495 stimulated by PKCα, not via NADPH oxidase. These results provide support for the use of pyridoxine in ox-LDL-related vascular endothelial dysfunction.