DNA methylation‐based prognosis and epidrivers in hepatocellular carcinoma

2015443 citationsJournal Articlegreen Open Access

Authors

Augusto Villanueva · Institut d'Investigació Biomédica de Bellvitge

Anna Portela · Department of Physiological Sciences

Sergi Sayols · Institute of Molecular Biology

Carlo Battiston · Icahn School of Medicine at Mount Sinai

Yujin Hoshida · Institut d'Investigació Biomédica de Bellvitge

Jesús Méndez‐González · Universitat de Barcelona

Sandrine Imbeaud

Abstract

A validated signature of 36 DNA methylation markers accurately predicts poor survival in patients with HCC. Patients with this methylation profile harbor messenger RNA-based signatures indicating tumors with progenitor cell features.

Topics & Keywords

Epigenetics and DNA Methylation Ferroptosis and cancer prognosis RNA modifications and cancer

UN Sustainable Development Goals

Reduced inequalities

Publication Details

Published in: Hepatology

Volume 61, Issue 6, pp. 1945-1956

DOI: 10.1002/hep.27732

Field-Weighted Citation Impact: 14.34