CYP4F2 gene polymorphism as a contributor to warfarin maintenance dose in Japanese subjects

201129 citationsJournal Articlebronze Open Access

Authors

Katsunori Nakamura · Gunma University

K. Obayashi · Gunma University Hospital

T. Araki · Gunma University

Tohru Aomori · Gunma University Hospital

Yukiyoshi Fujita · Gunma University Hospital

Yuko Okada · Gunma University

Masahiko Kurabayashi ·

Abstract

Although a significant inter-patient difference in warfarin maintenance dose was observed between the CYP4F2 CC and CT genotypes, serum S-warfarin concentration was not significantly different between them. An effect of CYP4F2 V433M polymorphism on warfarin maintenance dose was observed but was relatively small when compared to the effects of CYP2C9 and VKOR polymorphism.

Topics & Keywords

Pharmacogenetics and Drug Metabolism Eicosanoids and Hypertension Pharmacology Hormonal Regulation and Hypertension

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Clinical Pharmacy and Therapeutics

Volume 37, Issue 4, pp. 481-485

DOI: 10.1111/j.1365-2710.2011.01317.x

Field-Weighted Citation Impact: 4.73