The insulin degrading enzyme activates ubiquitin and promotes the formation of K48 and K63 diubiquitin

201528 citationsJournal Article

Authors

Giuseppe Grasso · University of Catania

Valeria Lanza · Institute of Biostructure and Bioimaging

Gaetano Malgieri · University of Naples Federico II

Roberto Fattorusso · University of Naples Federico II

Adriana Pietropaolo · Magna Graecia University

Enrico Rizzarelli · Institute of Biostructure and Bioimaging

Danilo Milardi

Abstract

We report an ATP-dependent ubiquitin conjugation with IDE which, in turn, promotes Ub-Ub linkages in tube tests. We propose a novel function for IDE as a non-canonical ubiquitin activating enzyme.

Topics & Keywords

Ubiquitin and proteasome pathways Histone Deacetylase Inhibitors Research Peptidase Inhibition and Analysis

Publication Details

Published in: Chemical Communications

Volume 51, Issue 86, pp. 15724-15727

DOI: 10.1039/c5cc06786c

Field-Weighted Citation Impact: 1.60

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The insulin degrading enzyme activates ubiquitin and promotes the formation of K48 and K63 diubiquitin

Authors

Abstract

Topics & Keywords

Publication Details