Pharmacokinetics of combined treatment with praziquantel and albendazole in neurocysticercosis

201170 citationsJournal Articlebronze Open Access

Authors

Héctor H. Garcı́a · Universidad Peruana Cayetano Heredia

Andrés G. Lescano · Naval Medical Research Unit Six

Vera Lúcia Lanchote · Universidade de São Paulo

E. Javier Pretell · Instituto Nacional de Ciencias Neurológicas

Isidro Gonzáles · Instituto Nacional de Ciencias Neurológicas

Javier A. Bustos · Universidad Peruana Cayetano Heredia

Osvaldo Massaiti Takayanagui

Abstract

Combined ABZ + PZQ is associated with increased albendazole sulfoxide plasma concentrations. These increased concentrations could independently contribute to increased cysticidal efficacy by themselves or in addition to a possible synergistic effect.

Topics & Keywords

Parasitic infections in humans and animals Parasite Biology and Host Interactions Parasites and Host Interactions

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Clinical Pharmacology

Volume 72, Issue 1, pp. 77-84

DOI: 10.1111/j.1365-2125.2011.03945.x

Field-Weighted Citation Impact: 5.22