Aging of mesenchymal stem cell in vitro

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Authors

Mandana Mohyeddin Bonab · Tehran University of Medical Sciences

Kamran Alimoghaddam · Shariati Hospital

Fatemeh Talebian · Tehran University of Medical Sciences

Seyed H. Ghaffari · Tehran University of Medical Sciences

Ardeshir Ghavamzadeh · Shariati Hospital

Behrouz Nikbin · Tehran University of Medical Sciences

Abstract

We believe that MSC enter senescence almost undetectably from the moment of in vitro culturing. Simultaneously these cells are losing their stem cell characteristics. Therefore, it is much better to consider them for cell and gene therapy early on.

Topics & Keywords

Mesenchymal stem cell research Telomeres, Telomerase, and Senescence Tissue Engineering and Regenerative Medicine

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: BMC Cell Biology

Volume 7, Issue 1, pp. 14-14

DOI: 10.1186/1471-2121-7-14

Field-Weighted Citation Impact: 11.90