Amyloid-like aggregates of neuronal tau induced by formaldehyde promote apoptosis of neuronal cells

200786 citationsJournal Articlegold Open Access

Authors

Chun Lai Nie · State Key Laboratory of Brain and Cognitive Science

Xing Sheng Wang · State Key Laboratory of Brain and Cognitive Science

Ying Liu · State Key Laboratory of Brain and Cognitive Science

Rong He · University of Chinese Academy of Sciences

Abstract

The results suggest that low concentrations of formaldehyde can induce human tau protein to form neurotoxic aggregates, which could play a role in the induction of tauopathies.

Topics & Keywords

Alzheimer's disease research and treatments Prion Diseases and Protein Misfolding Parkinson's Disease Mechanisms and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: BMC Neuroscience

Volume 8, Issue 1, pp. 9-9

DOI: 10.1186/1471-2202-8-9

Field-Weighted Citation Impact: 2.74