A role for transient receptor potential vanilloid 4 in tonicity‐induced neurogenic inflammation

2010100 citationsJournal Articlebronze Open Access

Authors

Nathalie Vergnolle · Centre de Physiopathologie de Toulouse-Purpan

Nicolas Cénac · Université Toulouse III - Paul Sabatier

Christophe Altier · University of Calgary

Laurie Cellars

Kevin Chapman

Gerald W. Zamponi · University of Calgary

Serena Materazzi · Center for Translational Neurophysiology of Speech and Communication

Romina Nassini

Abstract

Activation of TRPV4 stimulates neuropeptide release from afferent nerves and induces neurogenic inflammation. This mechanism may mediate the generation and maintenance of inflammation after injury and during diseases, in which there are changes in extracellular osmolarity. Antagonism of TRPV4 may offer a therapeutic approach for inflammatory hyperalgesia and chronic inflammation.

Topics & Keywords

Ion Channels and Receptors Cardiovascular, Neuropeptides, and Oxidative Stress Research Pain Mechanisms and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Pharmacology

Volume 159, Issue 5, pp. 1161-1173

DOI: 10.1111/j.1476-5381.2009.00590.x

Field-Weighted Citation Impact: 3.43