Bioengineering Human Myocardium on Native Extracellular Matrix

2015334 citationsJournal Article

Authors

Jacques P. Guyette · Worcester Polytechnic Institute

Jonathan M. Charest · Worcester Polytechnic Institute

Robert W. Mills · Worcester Polytechnic Institute

Bernhard J. Jank · Harvard University

Philipp T. Moser · Worcester Polytechnic Institute

Sarah E. Gilpin · Harvard University

Joshua R. Gershlak

Abstract

Native cardiac extracellular matrix scaffolds maintain matrix components and structure to support the seeding and engraftment of human induced pluripotent stem cell-derived cardiomyocytes and enable the bioengineering of functional human myocardial-like tissue of multiple complexities.

Topics & Keywords

Tissue Engineering and Regenerative Medicine Electrospun Nanofibers in Biomedical Applications 3D Printing in Biomedical Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Research

Volume 118, Issue 1, pp. 56-72

DOI: 10.1161/circresaha.115.306874

Field-Weighted Citation Impact: 33.09