Whole-Genome Sequencing of Growth Hormone (GH)-Secreting Pituitary Adenomas

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Authors

Niko Välimäki · University of Helsinki

Hande Demi̇r · University of Helsinki

Esa Pitkänen · University of Helsinki

Eevi Kaasinen · University of Helsinki

Atte Karppinen · Karsa (Finland)

Leena Kivipelto · Karsa (Finland)

Camilla Schalin‐Jäntti ·

Abstract

Somatotropinomas showed a low number of somatic genetic alterations. Whereas no novel recurrently mutated genes could be identified, the somatic landscape has potential to affect the Ca(2+) and ATP pathways known to be involved in the pituitary tumorigenesis. Further studies, eg, methylome and transcriptome analyses, are needed to investigate possible interplay between the recurrent chromosome losses and epigenetic factors.

Topics & Keywords

Pituitary Gland Disorders and Treatments Adrenal and Paraganglionic Tumors Glioma Diagnosis and Treatment

Publication Details

Published in: The Journal of Clinical Endocrinology & Metabolism

Volume 100, Issue 10, pp. 3918-3927

DOI: 10.1210/jc.2015-3129

Field-Weighted Citation Impact: 6.11

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Whole-Genome Sequencing of Growth Hormone (GH)-Secreting Pituitary Adenomas

Authors

Abstract

Topics & Keywords

Publication Details