MAP3K11/GDF15 axis is a critical driver of cancer cachexia

2015175 citationsJournal Articlegold Open Access

Authors

Lorena Lerner · AVEO Oncology (United States)

Julie Tao · AVEO Oncology (United States)

Qing Liu · AVEO Oncology (United States)

Richard Nicoletti · AVEO Oncology (United States)

Bin Feng · AVEO Oncology (United States)

Brian Krieger · AVEO Oncology (United States)

Elizabeth K. Mazsa

Abstract

The combination of correlative observations, gain of function, and loss of function experiments validated GDF15 as a key driver of cancer cachexia and as a potential therapeutic target for the treatment and/or prevention of this syndrome.

Topics & Keywords

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Cachexia Sarcopenia and Muscle

Volume 7, Issue 4, pp. 467-482

DOI: 10.1002/jcsm.12077

Field-Weighted Citation Impact: 6.44