Pharmacokinetic analysis of felodipine–grapefruit juice interaction based on an irreversible enzyme inhibition model

The modelling leads to the important conclusion that GFJ-felodipine interaction increases with increasing frequency and amount of GFJ ingestion, and that an interval of 2-3 days between GFJ intake and felodipine administration is necessary if GFJ-felodipine interaction is to be avoided.