Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1

2015109 citationsJournal Articlegold Open Access

Authors

Tina Seitz · Universitätsmedizin Göttingen

Robert Stalmann · Universitätsmedizin Göttingen

Nawar Dalila · University of Göttingen

Jiayin Chen · Universitätsmedizin Göttingen

Sherin Pojar · University of Göttingen

Joao N.S. Pereira · Universitätsmedizin Göttingen

Ralph Krätzner ·

Abstract

Comprehensive genetic analyses showed strong global variations in the frequency of loss of OCT1 activity with selection pressure for maintaining OCT1 activity in East Asia and Oceania. These results not only enable pharmacogenetically-based optimization of drug treatment worldwide, but may help elucidate the functional role of human OCT1.

Topics & Keywords

Drug Transport and Resistance Mechanisms Folate and B Vitamins Research Metabolism and Genetic Disorders

Publication Details

Published in: Genome Medicine

Volume 7, Issue 1, pp. 56-56

DOI: 10.1186/s13073-015-0172-0

Field-Weighted Citation Impact: 3.45

Command Palette

Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1

Authors

Abstract

Topics & Keywords

Publication Details